Control of Developmental Regulators by Polycomb in Human Embryonic Stem Cells
نویسندگان
چکیده
Tong Ihn Lee, Richard G. Jenner, Laurie A. Boyer, Matthew G. Guenther, Stuart S. Levine, Roshan M. Kumar, Brett Chevalier, Sarah E. Johnstone, Megan F. Cole, Kyo-ichi Isono, Haruhiko Koseki, Takuya Fuchikami, Kuniya Abe, Heather L. Murray, Jacob P. Zucker, Bingbing Yuan, George W. Bell, Elizabeth Herbolsheimer, Nancy M. Hannett, Kaiming Sun, Duncan T. Odom, Arie P. Otte, Thomas L. Volkert, David P. Bartel, Douglas A. Melton, David K. Gifford, Rudolf Jaenisch, and Richard A. Young* Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA Developmental Genetics Group, RIKEN Center for Allergy and Immunology, 1-7-22, Suehiro, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan Technology and Development Team for Mammalian Cellular Dynamics, BioResource Center, RIKEN Tsukuba Institute, 3-1-1, Koyadai, Tsukuba, Ibaraki 230-0045, Japan Swammerdam Institute for Life Sciences, University of Amsterdam, 1098 SM Amsterdam, The Netherlands Howard Hughes Medical Institute, Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA MIT CSAIL, 32 Vassar Street, Cambridge, MA 02139, USA These authors contributed equally to this work. *Contact: [email protected] DOI 10.1016/j.cell.2006.02.043
منابع مشابه
Comments on control of developmental regulators by polycomb in human embryonic stem cells.
Polycomb group proteins are essential for early development in metazoans, but their contributions to human development are not well understood. We have mapped the Polycomb Repressive Complex 2 (PRC2) subunit SUZ12 across the entire nonrepeat portion of the genome in human embryonic stem (ES) cells. We found that SUZ12 is distributed across large portions of over two hundred genes encoding key d...
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ورودعنوان ژورنال:
- Cell
دوره 125 شماره
صفحات -
تاریخ انتشار 2006